2p1q

Overview
Click on this link to see a close-up view of auxin recognition in the active site. Auxin, shown here with green carbon atoms, is recognized by ARG403 (shown in blue) which forms hydrogen bonds with the acidic group. The aromatic portion of auxin is recognized by a pocket composed of hydrophobic amino acids, shown in white here. Auxin promotes the association of TIR1 ubiquitin ligase with its protein substrates by acting as "molecular glue" between the molecules. This structure includes a short peptide from one of the protein substrates, shown here in pink in a backbone representation or all atoms.

To see the similar interaction of the herbicide 2,4-D in this active site, see the entry for 2p1n.

About this Structure
2P1Q is a Protein complex structure of sequences from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference
Mechanism of auxin perception by the TIR1 ubiquitin ligase., Tan X, Calderon-Villalobos LI, Sharon M, Zheng C, Robinson CV, Estelle M, Zheng N, Nature. 2007 Apr 5;446(7136):640-5. PMID:17410169

Page seeded by OCA on Tue Jul 29 06:21:59 2008